ABSTRACT
Pituitary adenoma, the most common benign tumor in brain, its symptoms mainly include impaired visual function and endocrine hormone disorder. Visual acuity decline and visual field defect are the first symptoms, because of the special position of pituitary and optic chiasma, patients are often first seen in the ophthalmology department. Visual field examination and optical coherence tomography(OCT)can determine the degree of visual field defect and fundus condition. Electrophysiology examination can determine whether the optic nerve is damaged. All of them can be used as evaluation indexes of visual function in patients with pituitary adenoma. As an imaging tool, functional magnetic resonance, a derivative technique, has been used to study the texture of pituitary adenoma and optic nerve integrity in recent years. These comprehensive and detailed examinations can determine the best time for treatment and improve quality of life for patients. This article reviews the application of ophthalmic examination(visual field, OCT and electrophysiology)and functional magnetic resonance in pituitary adenoma.
ABSTRACT
AIM: To measure the macular thickness of normal young people by 3D 1000 optical coherence tomography (OCT) and study the repeatability of measuring results and the relationship between the thicknesses of macular and gender. At the same time, to compare our result with the data of other types of OCT, and to understand the consistency of the measuring results of macular thickness of different types of OCT. METHODS: Totally 222 eyes in 111 young people were detected using 3D scan mode of Topcon 3D OCT 1000 (ver 2.4 ) . Twelve cases ( 24 eyes ) underwent repeatability check. We took transverse comparison between our measured results with other research's results. RESULTS: There were 111 cases of young people, whose age were from 18-27 years old, all uncorrected and corrected visual acuity were≥1. 0, all intraocular pressure were CONCLUSION:The repeatability of macular examination is good. The central macular thickness can be better repeated than the center thickness. The central macular thickness is 229. 00±18. 20μm in young people, according to the 3D 1000 OCT measurements. There are statistical difference of central macular thickness between different genders.
ABSTRACT
Objective To investigate the pathogenesis of the expression and activation of signal transducers and activator of transcription(STAT) 6 in patients with ulcerative colitis(UC).Methods Thirty patients with active UC(diagnosed with colonoscopy with pathologicaly conformation),who were not treated with steroids or immunomodulators,and 30 age-matched healthy controls were studied.The expressions of phosphorylated STAT6 and non-phosphorylated STAT6 in nucleus and cytoplasm were deterimined by Western blot.DNA binding activity of STAT6 was tested by electrophoresis mobility shift assay(EMSA).Results The expression of phosphorylated STAT6 was higher in nucleus than that in cytoplasm in mild UC patients,but the expression was higher in cytoplasm than that in nucleus in moderate to sever UC patients (P